NaNog: A pluripotency homeobox (master) molecule
نویسندگان
چکیده
منابع مشابه
NaNog: A pluripotency homeobox (master) molecule
One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed "necessary", then at a specified time can differentiate into any type of cell. This fundamental process is required during organogenesis in foetal life and importantly during tissue repair in health and disease. Pluripotency is very tightly regul...
متن کاملThe pluripotency rheostat Nanog functions as a dimer.
The defining activity of the homeodomain protein Nanog is the ability to confer cytokine-independent self-renewal upon ES (embryonic stem) cells in which it is overexpressed. However, the biochemical basis by which Nanog achieves this function remains unknown. In the present study, we show that Nanog dimerizes through a functionally critical domain. Co-immunoprecipitation of Nanog molecules tag...
متن کاملIncreased expression of the pluripotency markers sex-determining region Y-box 2 and Nanog homeobox in ovarian endometriosis
BACKGROUND The precise etiology of endometriosis is not fully understood; the involvement of stem cells theory is a new hypothesis. Related studies mainly focus on stemness-related genes, and pluripotency markers may play a role in the etiology of endometriosis. We aimed to analyze the transcription pluripotency factors sex-determining region Y-box 2 (SOX2), Nanog homeobox (NANOG), and octamer-...
متن کاملActivin/Nodal signalling maintains pluripotency by controlling Nanog expression.
The pluripotent status of embryonic stem cells (ESCs) confers upon them the capacity to differentiate into the three primary germ layers, ectoderm, mesoderm and endoderm, from which all the cells of the adult body are derived. An understanding of the mechanisms controlling pluripotency is thus essential for driving the differentiation of human pluripotent cells into cell types useful for clinic...
متن کاملNanog, Oct4 and Tet1 interplay in establishing pluripotency
A few central transcription factors inside mouse embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are believed to control the cells' pluripotency. Characterizations of pluripotent state were put forward on both transcription factor and epigenetic levels. Whereas core players have been identified, it is desirable to map out gene regulatory networks which govern the reprogrammin...
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ژورنال
عنوان ژورنال: Global Cardiology Science and Practice
سال: 2015
ISSN: 2305-7823
DOI: 10.5339/gcsp.2015.36